International Graduate School of Neuroscience

Research Interests

Prof. Dr. Jeremias Motte is a senior consultant neurologist and head of the neuroimmunological research laboratory at the Department of Neurology, University Hospital Bochum. As a W1TTW2 professor for the immunophenotyping of neuroimmunological diseases, his translational research focuses on both central and peripheral nervous system autoimmunity.

A central aspect of his work is the development of patient cohorts and biobanks to establish multimodal models of neuroimmunological disorders. These efforts aim to enhance mechanistic understanding and inform therapeutic strategies across diseases.

His group maintains a hiPSC-based cell culture platform to model disease processes in vitro. Using neuronal and astrocytic readouts, the influence of human biospecimens on cell function is assessed.
Methodologically, the laboratory covers a broad range of immunological techniques including live-cell imaging, suppression assays, flow cytometry (FACS), and various immunoassays.
A second major clinical and scientific focus is the investigation and application of cell-based immunotherapies in neuroimmunology. This includes CAR T cell therapy, hematopoietic stem cell transplantation, and T cell engagers such as bi- and trispecific antibodies. The field of neuroimmunological cell therapy is rapidly evolving and holds high relevance for both translational science and future patient care.

Prof. Motte is embedded in a wide collaborative network, including several departments at Ruhr University Bochum and international partners in both clinical and basic neuroscience. He maintains close collaborations with IGSN members PD Dr. Kalliopi Pitarokoili, Dr. Melissa Sgodzai, and Prof. Dr. Katrin Marcus.

His research group welcomes applications for Bachelor’s and Master’s theses from students in biology as well as medical doctoral theses.